Thermo Fisher Scientific CD38 Monoclonal Antibody (HIT2)
CD38 단백질을 인식하는 마우스 모노클로날 항체로, 인간 시료에 반응합니다. IHC, WB, Flow Cytometry 등 다양한 실험에 사용 가능하며, 액상 형태로 제공됩니다. 단백질 A로 정제되었으며 4°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL | - |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Flow Cytometry (Flow) | 1–4 µg/mL | 17 publications |
| Miscellaneous PubMed (Misc) | - | 6 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HIT2 |
| Immunogen | Fetal human thymocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1072231 |
Available Conjugated Formats
Product Specific Information
This antibody reacts with an extracellular epitope of CD38, a 45 kDa type II transmembrane glycoprotein strongly expressed mainly on plasma cells and activated T and B lymphocytes. It serves as an antigenic marker of lymphoid cells. Its binding is blocked by daratumumab.
A suggested positive control for this product is RAJI human cells.
Western Blot: non-reducing conditions.
Target Information
CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein involved in activation, proliferation, and differentiation of mature lymphocytes and mediating apoptosis of myeloid and lymphoid progenitor cells.
It functions as a multi-catalytic ectoenzyme with ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and NAD+ glycohydrolase activities or as a cell surface receptor.
Antibodies to CD38 are useful for subtyping lymphomas and leukemias, detecting plasma cells (e.g., myeloma identification), and as markers for activated B and T cells.
CD38 participates in cell adhesion, signal transduction, and calcium signaling, and is highly expressed in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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