Thermo Fisher Scientific HLA-ABC Monoclonal Antibody (MEM-123)

Applications

Product Specifications

Additional Formats

• PE
• Request custom conjugation

Product Specific Information

This antibody reacts with an extracellular epitope of all human classical MHC Class I molecules (major histocompatibility complex) in native cell-surface forms as well as with human HLA-G cDNA transfected cells.
MHC Class I molecules (MHC Class Ia) are expressed on the surface of all human cell types.
The antibody MEM-123 completely blocks binding of classical W6/32 to surface-expressed HLA-G, but does not cross-block the antibody MEM-G/9.

Target Information

HLA-class I major histocompatibility (MHC) antigens are intrinsic membrane glycoproteins expressed on nucleated cells and noncovalently associated with an invariant beta2 microglobulin.
They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumor defense.
Human HLA-class I antigens are represented by HLA-A, HLA-B, and HLA-C molecules.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.