
Thermo Fisher Scientific FAS Monoclonal Antibody (LT95)
FAS(CD95) 단백질을 인식하는 LT95 클론 단일클론 항체로, 인간 시료에 반응합니다. IHC(P) 및 Flow Cytometry에 사용 가능하며, 액상형 1 mg/mL 농도로 제공됩니다. Protein A로 정제되었으며 PBS(pH 7.4)에 15mM sodium azide가 포함되어 있습니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent |
| Flow Cytometry (Flow) | 1–12 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LT95 |
| Immunogen | T cell lymphoma cells HUT-78 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1073499 |
Additional Conjugate Formats
Product Specific Information
This antibody recognizes a functional epitope of the Fas molecule.
Target Information
FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein functioning as a cell death receptor of the TNFR superfamily. It also exists in a soluble form (~26 kDa). Stimulation of FAS leads to aggregation of intracellular FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC), and activation of caspases. This cascade triggers apoptosis and can also activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK pathways. FAS is involved in proliferation signaling in normal fibroblasts and T cells. Multiple isoforms exist due to alternative splicing, with some lacking the transmembrane domain and acting as negative regulators of apoptosis. The Fas/Fas ligand system is implicated in diseases such as AIDS, hepatitis, and cancer, and plays a key role in antiviral immune responses.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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