Thermo Fisher Scientific CD1a Monoclonal Antibody (HI149)
인간 CD1a 단백질을 인식하는 마우스 단클론 항체로, IHC(P), IHC(F), Flow Cytometry에 사용 가능. 비결합형(Unconjugated) 형태이며 1 mg/mL 농도의 액상 시약. Protein A로 정제되어 있으며, 4°C 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Flow Cytometry (Flow) | 1–5 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HI149 |
| Immunogen | Human thymocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1071456 |
Available Conjugated Formats
Product Specific Information
This antibody reacts with an extracellular epitope of CD1a (T6), a 49 kDa polypeptide associated with beta2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells, and some T-cell leukemias and lymphomas.
It does not react with peripheral blood T and B lymphocytes, monocytes, granulocytes, platelets, or erythrocytes.
Target Information
CD1a is a non-polymorphic MHC Class I–related cell surface glycoprotein expressed in association with beta-2 microglobulin. It is present on cortical thymocytes, Langerhans cells, dendritic cells, and certain T-cell leukemias.
CD1a mediates the presentation of lipid and glycolipid antigens to T cells. The human genome contains five CD1 family genes (CD1a–e), which differ in localization and lipid ligand specificity. CD1a primarily localizes to the plasma membrane and early endocytic vesicles.
Alternative splicing variants of CD1a have been observed, though their biological significance remains unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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