Thermo Fisher Scientific Factor VII Monoclonal Antibody (406722)

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

-

Immunoprecipitation (IP)

25 µg/mL

-

Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rat / IgG1

Class

Monoclonal

Type

Antibody

Clone

406722

Immunogen

CHO-derived recombinant mouse Coagulation Factor VII Ala42-Leu446 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Factor VII,uniProtId:P70375-1,ncbiNodeId:10090,antigenRange:42-446,antigenLength:446,antigenImageFileName:MA5-24143_Factor_VII_P70375-1_Rat.svg,antigenImageFileNamePDP:MA5-24143_Factor_VII_P70375-1_Rat_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2608291

Product Specific Information

In direct ELISAs, no cross-reactivity with recombinant human (rh) FGFA, rhFactor VII, rhFactor X, rhFactor XI, rhPROC, rhThrombin, rhUPA1, rhKLK-1, -2, -3, -4, -5, -7, -8, -9, -10, -11, -12, -13, -14, -15, or -B1 is observed.

Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

Coagulation factor VII is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in F7 production can cause coagulopathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.