Thermo Fisher Scientific PIR-A/PIR-B Monoclonal Antibody (404127)

Applications

Flow Cytometry (Flow)

• Tested Dilution: 2.5 µg per million cells

Product Specifications

Product Specific Information

Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

Paired Ig-like receptors of activating (PIR)-A and -B are expressed on B lymphocytes, macrophages, dendritic cells, platelets, granulocytes, and mast cells, but not on T cells, NK cells, and erythrocytes.
These cell surface glycoproteins contain six extracellular Ig-like domains with distinct cytoplasmic and transmembrane regions.
The PIR-A receptor activates through signaling molecules containing immunoreceptor tyrosine-based activation motifs, whereas the PIR-B receptor inhibits through proteins possessing immunoreceptor tyrosine-based inhibitory motifs.
PIRs bind MHC class I to modulate immune system homeostasis and cell signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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