Thermo Fisher Scientific PIR-A/PIR-B Monoclonal Antibody (404127)
Thermo Fisher Scientific의 PIR-A/PIR-B 단클론 항체(404127)는 마우스 PIR-A/B 단백질을 표적하는 Rat IgG2a 형 항체로, Flow Cytometry에 적합합니다. 단백질 A/G로 정제된 동결건조 형태이며, 연구용으로 면역 조절 및 세포 신호 분석에 활용됩니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 2.5 µg per million cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 404127 |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse PIR-A1 Gly24–Met650 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2576219 |
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Paired Ig-like receptors of activating (PIR)-A and -B are expressed on B lymphocytes, macrophages, dendritic cells, platelets, granulocytes, and mast cells, but not on T cells, NK cells, and erythrocytes.
These cell surface glycoproteins contain six extracellular Ig-like domains with distinct cytoplasmic and transmembrane regions.
The PIR-A receptor activates through signaling molecules containing immunoreceptor tyrosine-based activation motifs, whereas the PIR-B receptor inhibits through proteins possessing immunoreceptor tyrosine-based inhibitory motifs.
PIRs bind MHC class I to modulate immune system homeostasis and cell signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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