Thermo Fisher Scientific PIR-A/PIR-B Monoclonal Antibody (404127)

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

2.5 µg per million cells

-

Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rat / IgG2a

Class

Monoclonal

Type

Antibody

Clone

404127

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse PIR-A1 Gly24-Met650 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PIR-A/PIR-B,uniProtId:P97484-1,ncbiNodeId:10090,antigenRange:24-650,antigenLength:841,antigenImageFileName:MA5-24140_PIR-APIR-B_P97484-1_Rat.svg,antigenImageFileNamePDP:MA5-24140_PIR-APIR-B_P97484-1_Rat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2576219

Product Specific Information

Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

Paired Ig-like receptors of activating (PIR)-A and -B are expressed on B lymphocytes, macrophages, dendritic cells, platelets, granulocytes, and mast cells, but not on T cells, NK cells, and erythrocytes. These cell surface glycoproteins contain six extracellular Ig-like domains with distinct cytoplasmic and transmembrane regions. The PIR-A receptor activates through signaling molecules containing immunoreceptor tyrosine-based activation motifs. In contrast, the PIR-B receptor inhibits through proteins possessing immunoreceptor tyrosine-based inhibitory motifs. PIRs bind MHC class I to modulate immune system homeostasis and cell signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.