Thermo Fisher Scientific CD63 Chimeric Recombinant Rabbit Monoclonal Antibody (NK-1-C3)
CD63 단백질을 인식하는 재조합 토끼 단클론 항체로, 인간 및 마우스 시료에 반응합니다. WB, IHC, ICC/IF, Flow, IP 등 다양한 응용에 적합합니다. HEK293 세포에서 발현되었으며 Protein A로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | NK-1-C3 |
| Immunogen | This antibody was raised by immunizing BALB/c mice with a plasma membrane preparation of the human melanoma MeWo cells. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074717 |
Product Specific Information
This antibody recognizes CD63. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation and plays a role in the activation of cellular signaling cascades.
Target Information
CD63 (LAMP-3, lysosome-associated membrane protein-3) is a glycoprotein of the tetraspanin family, present in late endosomes, lysosomes, and secretory vesicles of various cell types. It also appears on the plasma membrane following cell activation and serves as a basophil activation marker. CD63 interacts with integrins, affects phagocytosis and cell migration, and is involved in trafficking regulation of ROMK1 channels. It also functions as a T-cell costimulation molecule and can be used as a prognostic marker in carcinomas. CD63 is expressed on activated platelets, monocytes, macrophages, and weakly on granulocytes, B, and T cells. It is identical to melanoma-associated antigen ME491 and platelet antigen PTLGP40. Dysfunctions of CD63 are associated with melanoma and Hermansky-Pudlak Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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