Thermo Fisher Scientific CD63 Chimeric Recombinant Rabbit Monoclonal Antibody (NK-1-C3)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody recognizes CD63. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation and plays a role in the activation of cellular signaling cascades.

Target Information

CD63 (LAMP-3, lysosome-associated membrane protein-3) is a glycoprotein of the tetraspanin family, present in late endosomes, lysosomes, and secretory vesicles of various cell types. It also appears on the plasma membrane following cell activation and serves as a basophil activation marker. CD63 interacts with integrins, affects phagocytosis and cell migration, and is involved in trafficking regulation of ROMK1 channels. It also functions as a T-cell costimulation molecule and can be used as a prognostic marker in carcinomas. CD63 is expressed on activated platelets, monocytes, macrophages, and weakly on granulocytes, B, and T cells. It is identical to melanoma-associated antigen ME491 and platelet antigen PTLGP40. Dysfunctions of CD63 are associated with melanoma and Hermansky-Pudlak Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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