Thermo Fisher Scientific CD59 Chimeric Recombinant Rabbit Monoclonal Antibody (193-27)
인간 CD59 단백질을 특이적으로 인식하는 키메라 재조합 토끼 단클론 항체입니다. IHC, ICC/IF, FACS 등 다양한 응용에 사용 가능하며, HEK293 세포에서 발현되었습니다. 단백질 A로 정제된 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관이 권장됩니다.
- 카탈로그번호
- MA548273
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 193-27 |
| Immunogen | This antibody was raised by immunizing mice with stimulated human leukocytes. Target family: CD59 (UniProt ID: P13987-1), Antigen range: 1–128. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074715 |
Product Specific Information
This antibody recognizes human CD59, a GPI-anchored cell surface protein that regulates complement-mediated cell lysis and participates in lymphocyte signal transduction.
Target Information
CD59 (Protectin) is a small (18–20 kDa) GPI-anchored inhibitor of the membrane attack complex (MAC). It prevents complement-mediated damage to autologous cells by binding complement components C8 and/or C9, inhibiting C9 polymerization and pore formation. CD59 also functions as a low-affinity ligand for CD2, contributing to T-cell costimulation and signal transduction. Mutations in CD59 can cause CD59 deficiency, associated with hemolytic anemia, thrombosis, and cerebral infarction. Multiple alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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