Thermo Fisher Scientific CD63 Recombinant Mouse Monoclonal Antibody (NK-1-C3)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Specificity: This antibody recognizes CD63.
The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation and plays a role in the activation of cellular signaling cascades.

Target Information

CD63 (LAMP-3, lysosome-associated membrane protein-3) is a glycoprotein of the tetraspanin family present in late endosomes, lysosomes, and secretory vesicles of various cell types.
It translocates to the plasma membrane following cell activation, making it a widely used basophil activation marker.
In mast cells, CD63 exposure does not require activation. CD63 interacts with integrins, influences phagocytosis and cell migration, and is involved in H/K-ATPase trafficking and regulation of ROMK1 channels.
It also serves as a T-cell costimulation molecule.
Expression of CD63 can be used to predict prognosis in early-stage carcinomas.
CD63 is expressed on activated platelets, monocytes, and macrophages, and weakly on granulocytes, B, and T cells.
It is identical to the melanoma-associated antigen ME491 and the platelet antigen PTLGP40.
Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.