Thermo Fisher Scientific IKK alpha/beta Recombinant Rabbit Monoclonal Antibody (SN63-02)
IKK alpha/beta 단백질을 표적하는 Thermo Fisher의 재조합 토끼 모노클로날 항체. 높은 특이성과 민감도, 로트 간 일관성, 동물 유래 성분 없는 포뮬레이션. WB 및 ICC/IF 실험에 최적화된 연구용 항체.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SN63-02 |
| Immunogen | Recombinant protein within Human IKK beta aa 450–652 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809560 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
Target Information
IKK alpha/beta is encoded by CHUK and IKKB genes located on chromosomes 10 and 8 in humans. Upon NF-kB pathway activation (e.g., TNF alpha stimulation), IKK alpha and IKK beta, along with regulator NEMO (IKK gamma), phosphorylate IkB proteins. This leads to ubiquitin-mediated degradation and NF-kB phosphorylation, enabling nuclear translocation. Phosphorylation at serine 176 and 180 in the activation loop induces conformational changes required for kinase activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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