Thermo Fisher Scientific Phospho-STAT1 (Ser727) Recombinant Rabbit Monoclonal Antibody (SN67-04)
Phospho-STAT1 (Ser727)을 인식하는 재조합 토끼 단클론 항체로, 인간·마우스·랫에서 반응합니다. Western blot, IHC, ICC/IF에 적합하며 높은 특이성과 재현성을 제공합니다. Protein A 정제, 액상 형태, 1 mg/mL 농도이며 연구용으로 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SN67-04 |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding Ser727 of Human STAT1 (aa 701–750) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809557 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select optimal candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
STAT1 (Signal Transducers and Activators of Transcription 1) is a member of the STAT family of transcription factors. It is activated by interferon-alpha, interferon-gamma, EGF, PDGF, and IL6, and regulates genes involved in cell growth, apoptosis, immune responses, and lipid metabolism.
STAT1 plays a key role in mediating cell viability under various stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2.
Activation occurs via phosphorylation by JAK tyrosine kinases, enabling STAT1 to enter the nucleus and regulate gene transcription.
Among seven STAT types, STAT1, STAT3, STAT5a, and STAT5b have broad activation profiles. STAT1 is activated by ligands including:
- IFN family (IFN-Alpha, IFN-Beta, IFN-Gamma, IL-10)
- gp130 family (IL-6, IL-11, LIF, CNTF, G-CSF)
- Receptor tyrosine kinases (EGF, PDGF, CSF-1)
Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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