Thermo Fisher Scientific RAD18 Recombinant Rabbit Monoclonal Antibody (SN66-01)
RAD18 단백질을 인식하는 재조합 토끼 단클론 항체. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 사용 가능. 높은 특이성과 재현성을 제공하며, HEK293 세포에서 발현된 항체로 로트 간 일관성이 우수함. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | View 2 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | – |
| Flow Cytometry (Flow) | 1:50–1:100 | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SN66-01 |
| Immunogen | Synthetic peptide within Human RAD18 aa 50–99 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809569 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity to diverse targets due to the larger rabbit immune repertoire
Target Information
Human Rad18 (hRad18) is the homologue of S. pombe Rad18. In yeast, Rad6 and Rad18 play a crucial role in post-replication repair, filling gaps in the daughter strand during replication of damaged DNA. The Rad6–Rad18 interaction is critical for lesion bypass, forming a tight complex via a conserved ring-finger motif. The Rad18–Rad6 complex binds damaged DNA sites through the single-stranded DNA binding property of Rad18, followed by degradation of stalled replication components by the ubiquitin-conjugating activity of Rad6.
Human RAD18 maps to chromosome 3p24–25, a region often deleted in lung, breast, ovary, and testis cancers. The gene encodes a 495 amino acid protein (~56 kDa) that is ubiquitously expressed in various human tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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