Thermo Fisher Scientific CD23 Chimeric Recombinant Rabbit Monoclonal Antibody (CAT-13.9C1)
CD23 단백질을 인식하는 재조합 토끼 모노클로날 항체로, IgE 생산 조절 및 B세포 분화 연구에 적합. 인간 시료 반응성, ICC/IF 및 Flow Cytometry 검증 완료. HEK293 발현 시스템, Protein A 정제, 액상 형태로 제공.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | CAT-13.9C1 |
| Immunogen | This antibody was raised by immunising mice with an EBV-transformed human B cell line from a patient with MHC class II deficiency re-expressing class II antigens. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074703 |
Product Specific Information
Specificity: This antibody recognises CD23, a low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. It plays essential roles in the regulation of IgE production and in the differentiation of B cells.
Target Information
CD23 is a 45 kDa glycoprotein present on a subpopulation of freshly isolated peripheral blood and tonsil B cells, and is strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE receptor found on B cells. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some cases of centroblastic/centrocytic lymphoma. Functionally, CD23 is involved in B cell growth and differentiation, and IgE production. CD23 also has a soluble form that acts as a potent mitogenic factor. Diseases associated with CD23 dysfunction include chronic conjunctivitis and chronic lymphocytic leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: MA5-48261_CD23_P06734-1_Rabbit.svg, MA5-48261_CD23_P06734-1_Rabbit_PDP.jpeg)
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