Thermo Fisher Scientific CD31 (PECAM-1) Chimeric Recombinant Rabbit Monoclonal Antibody (BAG-85D10)
CD31(PECAM-1)을 인식하는 Thermo Fisher의 키메라 재조합 토끼 단일클론 항체로, IHC, ICC/IF, Flow Cytometry에 사용 가능. 인간 시료 반응성, HEK293 발현, Protein A 정제. 염증 시 백혈구 이동 및 혈관 내 세포 간 상호작용 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BAG-85D10 |
| Immunogen | This antibody was raised by immunising mice with human peripheral blood lymphocytes from a patient with high numbers of gamma-delta T cells. Target: CD31 (PECAM-1), UniProt ID: P16284-1, Antigen range: 1–738 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074702 |
Product Specific Information
This antibody recognises CD31 (PECAM1), a member of the immunoglobulin superfamily expressed on circulating cells such as neutrophils, monocytes, platelets, and endothelial cells. CD31 functions as a cell adhesion molecule involved in leukocyte transendothelial migration during inflammation.
Target Information
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor regulating T and B cell signaling via dual ITIM motifs that, upon phosphorylation, provide docking sites for protein-tyrosine phosphatases. CD31 is ubiquitously expressed in the vascular compartment, mainly at cell junctions. Its N-terminal Ig-like domain mediates homophilic binding, crucial for cell-cell interactions. CD31 plays roles in integrin-mediated adhesion, transendothelial migration, angiogenesis, apoptosis, immune regulation, macrophage phagocytosis, IgE-mediated anaphylaxis, and thrombosis, making it a key regulator in vascular biology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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