Thermo Fisher Scientific Gemin5 Polyclonal Antibody
Gemin5 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IP에 사용 가능. 4°C에서 보관하며, 액상 형태로 제공. SMN 복합체 관련 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1410 and 1438 of human gem (nuclear organelle) associated protein 5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
The SMN complex plays a catalytic role in the assembly of small nuclear ribonucleoproteins (snRNPs), which are essential components of the spliceosome and play an important role in pre-mRNA splicing.
Most spliceosomal snRNPs contain a common set of Sm proteins (SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, and SNRPG) that form a heptameric ring on the Sm site of small nuclear RNA to create the core snRNP.
In the cytosol, these Sm proteins are initially sequestered in an inactive 6S pICln-Sm complex by the chaperone CLNS1A. The SMN complex dissociates CLNS1A and facilitates assembly of the active core snRNPs for nuclear transport.
GEMIN5 functions as the snRNA-binding protein of the SMN complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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