Thermo Fisher Scientific Gemin5 Polyclonal Antibody
Rabbit에서 유래한 Gemin5 단클론 항체로 Western blot과 Immunoprecipitation에 적합. 인간 Gemin5 단백질(1360–1410 aa)을 면역원으로 사용. 0.2 mg/mL 농도의 액상 형태로 제공되며 4°C에서 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1360 and 1410 of human Gemin5 (nuclear organelle associated protein 5) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The SMN complex plays a catalytic role in the assembly of small nuclear ribonucleoproteins (snRNPs), which are essential components of the spliceosome and play a critical role in pre-mRNA splicing. Most spliceosomal snRNPs contain a common set of Sm proteins (SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, and SNRPG) that assemble into a heptameric ring on the Sm site of small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins are held in an inactive 6S pICln-Sm complex by the chaperone CLNS1A, which controls the assembly of the core snRNP. The SMN complex dissociates CLNS1A from the trapped Sm proteins and transfers them to the SMN-Sm complex, triggering the assembly of core snRNPs and their transport to the nucleus. GEMIN5 functions as the snRNA-binding protein within the SMN complex.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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