Thermo Fisher Scientific Gemin5 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

The SMN complex plays a catalytic role in the assembly of small nuclear ribonucleoproteins (snRNPs), which are essential components of the spliceosome and play a critical role in pre-mRNA splicing. Most spliceosomal snRNPs contain a common set of Sm proteins (SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, and SNRPG) that assemble into a heptameric ring on the Sm site of small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins are held in an inactive 6S pICln-Sm complex by the chaperone CLNS1A, which controls the assembly of the core snRNP. The SMN complex dissociates CLNS1A from the trapped Sm proteins and transfers them to the SMN-Sm complex, triggering the assembly of core snRNPs and their transport to the nucleus. GEMIN5 functions as the snRNA-binding protein within the SMN complex.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.