Thermo Fisher Scientific Phospho-TDP-43 (Ser409, Ser410) Polyclonal Antibody
TDP-43 단백질의 Ser409/410 인산화 부위를 인식하는 폴리클로날 항체. Western blot, IHC, ICC/IF에 적합하며 사람, 마우스, 랫트 시료에서 반응. 1 mg/mL 농도의 액상 형태로 제공되며 -20°C에서 보관.
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- PA5114661
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TDP43 around the phosphorylation site of Ser409/410 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899297 |
Product Specific Information
This antibody detects endogenous levels of TDP43 only when phosphorylated at Ser409/410.
Target Information
TDP43 was first identified as a novel cellular protein that binds to HIV-1 TAR DNA sequence motifs and acts as a transcriptional repressor to the HIV-1 LTR. It also regulates splicing of exon 9 of the cystic fibrosis transmembrane conductance regulator (CFTR), likely through association with UG repeats at the 3′ splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 (pathologic TDP43) is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, an RNA-binding protein that binds HIV-1 TAR RNA sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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