Thermo Fisher Scientific Phospho-Tau (Ser673) Polyclonal Antibody
Phospho-Tau (Ser673) 폴리클로날 항체로 인간, 마우스, 랫트에 반응하며, Ser673에서 인산화된 Tau 단백질을 특이적으로 검출합니다. Western blot, IHC, ICC/IF에 적합하며, 고순도(1 mg/mL) 액상 형태로 제공됩니다. 알츠하이머병 관련 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAPT (Accession P10636), corresponding to amino acid residues around phosphorylated Ser673 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899289 |
Product Specific Information
Antibody detects endogenous levels of Tau only when phosphorylated at Ser673, which site historically referenced as Ser356.
Target Information
Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between the two. Tau localization determines axonal polarity within neurons. Short isoforms contribute to cytoskeletal plasticity, while longer isoforms aid stabilization. Hyper-phosphorylated Tau forms paired helical filaments (PHF), the main component of neurofibrillary lesions in Alzheimer’s disease (AD). This modification disrupts microtubule binding, leading to neuronal degeneration. Tau phosphorylation is mediated by kinases such as GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is also found in other neurodegenerative diseases, including Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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