Thermo Fisher Scientific Phospho-TSC2 (Ser939) Polyclonal Antibody
TSC2 단백질의 Ser939 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot 및 Immunohistochemistry에 사용 가능. Human, Mouse, Rat 반응성. PBS/50% glycerol 저장, -20°C 보관. 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TSC2 (Accession P49815), corresponding to amino acid residues around phosphorylated Ser939 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899303 |
Product Specific Information
This antibody detects endogenous levels of Tuberin/TSC2 only when phosphorylated at Ser939.
Target Information
TSC2 (Tuberin, Tuberous sclerosis complex, TSC Complex Subunit 2) acts as a tumor suppressor and may function in vesicular transport, regulation of cell growth arrest, and transcription mediated by steroid receptors.
TSC2 associates with hamartin (TSC1) in a cytosolic complex, possibly acting as a chaperone.
Phosphorylation of tuberin on Ser939 and Thr1462 regulates its interaction with hamartin and is stimulated by growth factors via the PI3K/Akt pathway.
Mutations in TSC2 are linked to diseases such as lymphangioleiomyomatosis and TSC2 angiomyolipoma.
Alternative splicing results in transcript variants of three different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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