Thermo Fisher Scientific LOX Monoclonal Antibody (OTI4E3), TrueMAB
인간 LOX 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot, IHC(P), ICC/IF에 사용 가능. 동결건조 형태로 제공되며 재구성 후 약 1 mg/mL 농도. 세포외기질 형성과 암 전이에 관련된 LOX 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4E3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22–168 of human LOX produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Lysyl oxidase (LOX) is a copper-containing amine oxidase that catalyzes the oxidation of primary amines to reactive aldehydes.
It plays a crucial role in extracellular matrix formation and repair, developmental regulation, tumor suppression, cell motility, and senescence.
Secreted LOX contributes to the invasive properties of hypoxic cancer cells, making it a key target for metastasis prevention and therapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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