Thermo Fisher Scientific LOX Monoclonal Antibody (OTI8G5), TrueMAB
LOX 단백질을 인식하는 Mouse Monoclonal Antibody로, Western blot, IHC(P), ICC/IF에 적합합니다. Human 시료에 반응하며, Lyophilized 형태로 제공됩니다. Affinity chromatography로 정제되었으며, ECM 형성 및 종양 전이 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8G5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22–168 of human LOX produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Lysyl oxidase (LOX) is a copper-containing amine oxidase that oxidizes primary amine substrates to reactive aldehydes. It plays a crucial role in the formation and repair of the extracellular matrix (ECM). LOX also has diverse biological functions, including developmental regulation, tumor suppression, cell motility, and cellular senescence. The secreted form of LOX contributes to the invasive properties of hypoxic human cancer cells, making it a key factor in hypoxia-induced metastasis and a potential therapeutic target for metastasis prevention and treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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