Thermo Fisher Scientific LOX Monoclonal Antibody (OTI9G2), TrueMAB
인간 LOX 단백질(aa 22–168)에 특이적인 마우스 IgG1 단클론 항체. WB, IHC, ICC/IF에 사용 가능. 무보존제, 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도 유지. 세포 이동, 종양 억제 및 ECM 형성 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9G2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22–168 of human LOX produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Lysyl oxidase (LOX) is a copper-containing amine oxidase involved in oxidizing primary amine substrates to reactive aldehydes.
It plays a crucial role in extracellular matrix formation and repair, developmental regulation, tumor suppression, cell motility, and cellular senescence.
The secreted form of LOX contributes to the invasive properties of hypoxic human cancer cells and is essential for hypoxia-induced metastasis, making it a potential therapeutic target for metastasis prevention and treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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