Thermo Fisher Scientific LOX Monoclonal Antibody (OTI7E6), TrueMAB
인간 LOX 단백질을 인식하는 마우스 단클론 항체로, Western blot, ICC/IF, Flow cytometry에 사용 가능. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용. 세포외 기질 형성과 종양 전이 연구에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7E6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22–168 of human LOX produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, an additional desalting step is recommended (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Lysyl oxidase (LOX) is a copper-containing amine oxidase involved in the oxidation of primary amines to reactive aldehydes.
It plays a crucial role in extracellular matrix formation and repair, and is associated with developmental regulation, tumor suppression, cell motility, and cellular senescence.
The secreted form of LOX contributes to the invasive properties of hypoxic human cancer cells, making it an important therapeutic target for preventing and treating metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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