Thermo Fisher Scientific TLR5 Monoclonal Antibody (2E1)
TLR5 단백질을 인식하는 Mouse IgG2b 단일클론 항체. 인간 시료에 반응하며 ELISA에 적합. 보존제가 없는 액상 형태로 제공되며 -20°C에서 보관. 선천면역 연구 및 세균성 플라젤린 감지 관련 연구에 활용 가능.
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Applications
- ELISA (ELISA): Tested dilution 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E1 |
| Immunogen | TLR5 (NP_003259.2, 351–450 a.a) partial recombinant protein with GST tag. MW of GST tag alone is 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Tissue culture supernatant |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
LYSSNFYGLP KVAYIDLQKN HIAIIQDQTF KFLEKLQTLD LRDNALTTIH FIPSIPDIFL SGNKLVTLPK INLTANLIHL SENRLENLDI LYFLLRVPHL
Target Information
TLR5 is a Type I membrane protein belonging to the Toll-like receptor family and participates in the innate immune response to microbial agents. It mediates detection of bacterial flagellins and acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion, and the inflammatory response.
TLR5 is highly expressed in liver, detected in lung, and at very low levels in most other tissues. The TLR5 gene locus is associated with susceptibility to Salmonella.
Inbred mouse strains show varying resistance to S. typhimurium:
- Susceptible: BALB/c, C57BL/6, C3H/He
- Intermediate: DBA/2, C75L
- Resistant: A, CBA
The strain MOLF/Ei is highly susceptible, has a unique TLR5 haplotype, and lower expression of TLR5.
A common TLR5 stop codon polymorphism disrupting TLR5 signaling is linked to susceptibility to Legionnaires’ disease, highlighting TLR5’s role in innate immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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