Thermo Fisher Scientific NR2E1 Monoclonal Antibody (2D10)
인간 NR2E1(TLX) 단백질을 인식하는 Mouse IgG2a 단일클론 항체로 ELISA에 적합합니다. 뇌 및 망막 발달 관련 연구용으로 사용되며, 비결합형 액상 형태로 제공됩니다. -20°C 보관, 동결/해동 반복 피해야 합니다.
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Applications
- ELISA (ELISA)
Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2D10 |
| Immunogen | NR2E1 (NP_003260, 249 a.a. ~ 342 a.a) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
NGDNTDSQKL NKIISEIQAL QEVVARFRQL RLDATEFACL KCIVTFKAVP THSGSELRSF RNAAAIAALQ DEAQLTLNSY IHTRYPTQPC RFGK
Target Information
Nuclear receptor TLX (NR2E1) is a hepatocyte NF4-like receptor involved in anterior brain differentiation, retinal development, and vision.
It regulates genes such as RAR beta2 and Pax2 during retinal development.
Homozygous TLX mutant mice show reduced forebrain development and increased aggression.
Deletion of TLX locus results in cerebral hypoplasia, blindness, and extreme aggression (fierce phenotype).
TLX expression is documented in mouse brain and eye, and ESTs have been isolated from normal human brain libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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