Thermo Fisher Scientific NMDAR2D Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total GRIN2D.

Target Information

Glutamate receptors mediate most excitatory neurotransmission in the brain and play important roles in neural plasticity, development, and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA and kainate/AMPA receptors, both containing glutamate-gated, cation-specific ion channels.
Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits (GluR-1 to -7).
Kainate/AMPA receptors mainly mediate fast excitatory neurotransmission, whereas NMDA receptors exhibit slow kinetics and high Ca²⁺ permeability.
NMDA receptors consist of five subunits: epsilon 1–4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem, while the epsilon subunits show limited distribution.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.