Thermo Fisher Scientific NMDAR2D Polyclonal Antibody
NMDAR2D 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, 인간, 생쥐, 랫트 시료에 반응합니다. Western blot 및 Immunocytochemistry에 적합하며, 고순도 친화 크로마토그래피로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GRIN2D (Accession O15399), corresponding to amino acid residues Y673–R723 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851042 |
Product Specific Information
Antibody detects endogenous levels of total GRIN2D.
Target Information
Glutamate receptors mediate most excitatory neurotransmission in the brain and play important roles in neural plasticity, development, and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA and kainate/AMPA receptors, both containing glutamate-gated, cation-specific ion channels.
Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits (GluR-1 to -7).
Kainate/AMPA receptors mainly mediate fast excitatory neurotransmission, whereas NMDA receptors exhibit slow kinetics and high Ca²⁺ permeability.
NMDA receptors consist of five subunits: epsilon 1–4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem, while the epsilon subunits show limited distribution.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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