Thermo Fisher Scientific MICA/B Monoclonal Antibody (6D4), Alexa Fluor 700
MICA 및 MICB 단백질의 공통 세포외 에피토프를 인식하는 Alexa Fluor 700 결합 단일클론 항체. CD314(NKG2D) 매개 NK 세포 및 세포독성 T 세포 활성 차단 가능. 인간 시료에 반응하며, Flow Cytometry에 적합. 4°C 암소 보관.
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Applications
- Flow Cytometry (Flow): 1–6 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6D4 |
| Immunogen | Transfected C1R cells expressing MICA |
| Conjugate | Alexa Fluor™ 700 |
| Excitation / Emission Max | 696 / 719 nm |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Size-exclusion chromatography |
| Storage buffer | PBS with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898636 |
Additional Formats
- Alexa Fluor 647 (MA5-38723)
- APC (MA5-38725)
- Biotin (MA5-38726)
- FITC (MA5-38727)
- PE-Cyanine7 (MA5-38728)
- Custom conjugation available upon request
Product Specific Information
This antibody recognizes a common extracellular epitope on MICA and MICB glycoproteins, transmembrane ligands of CD314 (NKG2D), and is able to block CD314-mediated activation of NK cells and cytotoxic T cells.
Target Information
MICA encodes the highly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface but does not associate with beta-2-microglobulin like canonical class I molecules. MICA is believed to function as a stress-induced antigen recognized by intestinal epithelial gamma delta T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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