
Thermo Fisher Scientific CD45 Monoclonal Antibody (2D1), PE-Cyanine5
인간 CD45 항원에 반응하는 마우스 단클론 항체로, PE-Cyanine5 형광 표지. Flow Cytometry에 적합하며, 모든 인간 혈액세포에서 높은 발현을 검출. 4°C 암소 보관, 동결 금지. 연구용 전용 제품.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 4 µL / 1×10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2D1 |
| Immunogen | Human peripheral blood mononuclear cells |
| Conjugate | PE-Cyanine5 |
| Excitation / Emission Max | 568 / 666 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898644 |
Available Formats
- Alexa Fluor 488
- Alexa Fluor 647
- APC-Cyanine7
- PerCP
- Custom conjugation available upon request
Product Specific Information
This antibody reacts with an extracellular epitope of all alternative forms of human CD45 antigen (Leukocyte Common Antigen), a 180–220 kDa single-chain type I transmembrane protein expressed at high levels on all cells of hematopoietic origin, except erythrocytes and platelets.
Target Information
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. It is absent on non-hematopoietic cell lines and tissues.
CD45 glycoprotein plays a critical role in lymphocyte development and antigen signaling, regulating Src-family kinases and cytokine receptor signaling. Multiple isoforms exist due to alternative splicing, differing in extracellular domains but sharing identical transmembrane and cytoplasmic regions.
CD45 is essential for T- and B-cell receptor signaling, modulation of integrin-mediated pathways, and apoptosis regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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