Thermo Fisher Scientific NEDD4 Polyclonal Antibody
NEDD4 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody. Western blot, ICC/IF, ELISA, IP 등 다양한 응용 가능. 인간, 말, 원숭이에 반응하며 고순도 affinity chromatography로 정제됨. 연구용으로만 사용.
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Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| ELISA | 1:20,000–1:35,000 |
| Immunoprecipitation (IP) | 1:300–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Horse, Human, Rhesus monkey |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to an internal portion of the Nedd4 protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.64 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
This antibody reacts with endogenous Nedd4 protein. A BLAST analysis suggests reactivity with Nedd4 from human, horse, and macaque based on 100% homology with the immunizing sequence.
Expect reactivity with Nedd4 from chimpanzee, rabbit, dog, and cattle based on 94% homology. Cross-reactivity with Nedd4 from other sources has not been determined.
Target Information
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein containing one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains.
It participates in the degradation of VEGFR-2/KDFR independently of its ubiquitin-ligase activity and acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination.
NEDD4 is also involved in viral budding and regulation of epithelial Na⁺ channels, contributing to arterial hypertension.
Localized to the sarcolemmal region of muscle fibers, increased NEDD4 expression is associated with muscle unloading and denervation, as well as decreased Notch1 expression, functioning as a down-regulator of Notch-1 gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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