Thermo Fisher Scientific NAG-1 Polyclonal Antibody
Human NAG-1 단백질의 아미노 말단 부위에 특이적으로 반응하는 Rabbit Polyclonal 항체. Western blot, IHC, ELISA, IP에 적합. 고순도 친화 크로마토그래피 정제. -20°C 보관, 반복 동결/해동 피할 것.
- 카탈로그번호
- 600-401-B10x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific NAG-1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:250–1:500 |
| Immunohistochemistry (IHC) | Assay-dependent |
| ELISA | 1:300,000 |
| Immunoprecipitation (IP) | 1:2,000–1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | This affinity purified antibody was prepared by repeated immunizations with a synthetic peptide corresponding to a region near the amino terminal end of human NAG-1 protein. A residue of cysteine was added to facilitate coupling to KLH. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.4 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid cycles of freezing and thawing.
- Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
This antibody specifically reacts with the amino terminal end of human NAG-1 protein from human tissues.
A BLAST analysis suggests partial reactivity with NAG-1 from chimpanzee and macaque based on 92% homology.
Multimeric forms of NAG-1 may be detected. Cross-reactivity with NAG-1 from other sources has not been determined.
Target Information
GDF-15 belongs to the TGF-beta cytokine family, which plays an important role in prenatal development, postnatal growth, and tissue maintenance.
It is predominantly expressed in the placenta and to a lesser extent in other tissues.
The presence of GDF-15 in amniotic fluid and its elevated levels in pregnant women suggest its involvement in gestation and embryonic development.
GDF-15 generally exerts tumor suppressive activities and is produced in response to activation of the p53 pathway.
Serum levels of GDF-15 are positively correlated with neoplastic progression in several tumor types, including colorectal, pancreatic, and prostate cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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