Thermo Fisher Scientific MYH9 Polyclonal Antibody
Human 및 Rat 시료에 반응하는 Rabbit Polyclonal MYH9 항체. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제됨. PBS/glycerol buffer에 보관, 단기 4°C, 장기 -20°C 저장 권장. 세포 이동, 부착, 분열 연구에 유용.
- 카탈로그번호
- PA586797
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in Human MYH9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2803557 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), an essential component of the actin cytoskeleton. It spans over 106 kb and includes 41 exons encoding a protein of 1,960 amino acids forming a hexameric complex (two heavy chains, two regulatory light chains, two essential light chains).
NMHC IIA interacts with actin filaments and is involved in cell migration, adhesion, division, and maintenance of cell shape. Mutations in MYH9 cause autosomal dominant MYH9-related diseases (MYH9-RD), including May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome, characterized by macrothrombocytopenia and potential complications such as hearing loss, renal failure, and cataracts.
MYH9 is also critical in hematopoiesis for maintaining hematopoietic stem and progenitor cells (HSPCs). Loss of MYH9 function leads to hematopoietic defects and bone marrow failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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