Thermo Fisher Scientific MYH9 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

Purity is >95% by SDS-PAGE.

Target Information

The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), an essential component of the actin cytoskeleton. It spans over 106 kb and includes 41 exons encoding a protein of 1,960 amino acids forming a hexameric complex (two heavy chains, two regulatory light chains, two essential light chains).
NMHC IIA interacts with actin filaments and is involved in cell migration, adhesion, division, and maintenance of cell shape. Mutations in MYH9 cause autosomal dominant MYH9-related diseases (MYH9-RD), including May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome, characterized by macrothrombocytopenia and potential complications such as hearing loss, renal failure, and cataracts.
MYH9 is also critical in hematopoiesis for maintaining hematopoietic stem and progenitor cells (HSPCs). Loss of MYH9 function leads to hematopoietic defects and bone marrow failure.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.