Thermo Fisher Scientific CD42b Polyclonal Antibody
인간 CD42b 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 최적화되어 있으며, 높은 순도(>95%)와 항원 친화 크로마토그래피 정제. 혈소판 활성화 및 응고 연구용으로 적합.
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Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in Human GP1BA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803559 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
CD42b is a platelet activation marker involved in coagulation as an aggregating factor. It interacts with extracellular matrix and adhesion molecules. CD42b expression and activation are regulated by VEGF and PDGF.
CD42b, together with GPIb beta, GPIX, and GPV, forms the GPIb-IX-V receptor complex critical for platelet-rich thrombus formation by tethering platelets to thrombogenic surfaces.
It binds to von Willebrand factor (VWF) at vascular injury sites, as well as thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1, and P-selectin.
The extracellular domain of CD42b contributes to metastasis through these interactions. CD42b antigen is expressed on platelets and megakaryocytes in bone marrow.
Several polymorphisms and mutations in CD42b have been described, some causing Bernard-Soulier syndromes and platelet-type von Willebrand disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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