Thermo Fisher Scientific BMPR1A Polyclonal Antibody
BMPR1A 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, ICC/IF, IP 등 다양한 응용에 사용 가능. Human 시료에 반응하며, 고순도의 액상 형태로 제공. 연구용으로 안정적인 장기 보관 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 | View 1 publication |
| Immunoprecipitation (IP) | - | View 1 publication |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 21–51 of the N-terminal region of human BMPR1A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10983970 |
Target Information
BMPR1A is a Type I member of the TGF-beta receptor superfamily of transmembrane serine/threonine kinases, which phosphorylate intracellular SMADs in response to bone morphogenic proteins. These receptors are closely related to activin receptors ACVR1 and ACVR2. Ligands of these receptors belong to the TGF-beta superfamily.
TGF-betas and activins signal through heteromeric complexes of two different types of serine/threonine kinase receptors:
- Type I receptors (~50–55 kDa)
- Type II receptors (~70–80 kDa)
Type II receptors can bind ligands independently but require type I receptors for signaling, whereas type I receptors depend on type II receptors for ligand binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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