Thermo Fisher Scientific Phospho-MEK3 (Ser189) Polyclonal Antibody
Phospho-MEK3 (Ser189) 특이적 폴리클로날 항체로, 인간 MKK3의 인산화 부위를 인식합니다. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 1 mg/mL 액상 형태로 제공됩니다. 연구용으로만 사용 가능하며, Thermo Fisher Scientific에서 공급합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MKK3 around the phosphorylation site of Ser189 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903059 |
Target Information
MAP2K3 (MEK3) is a dual-specificity protein kinase involved in cellular signal transduction pathways and is necessary for the expression of glucose transporter. It phosphorylates and activates MAPK14/p38-MAPK. This kinase can be activated by insulin and is necessary for glucose transporter expression. Expression of the RAS oncogene leads to accumulation of the active form of this kinase, resulting in constitutive activation of MAPK14 and oncogenic transformation of primary cells. Inhibition of this kinase is implicated in the pathogenesis of Yersinia pseudotuberculosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported for MEK3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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