Thermo Fisher Scientific Phospho-C/EBP alpha (Ser21) Polyclonal Antibody
인간 C/EBPα의 Ser21 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. 고농도(1 mg/mL) 액상 형태로 제공되며, -20°C 보관. 연구용으로만 사용 가능.
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- PA5118558
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human C/EBPα around the phosphorylation site of Ser21 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903060 |
Target Information
The C/EBP (CCAAT/enhancer binding protein) family of transcription factors—alpha, beta, delta, and epsilon—are widely expressed proteins found in a variety of tissues. These domains contain an evolutionarily conserved five-amino acid motif (regulatory domain motif, RDM) that conforms to the consensus sequence (I/V/L)KXEP.
One of the major roles of these transcription factors is metabolic regulation in liver and fat cells. Studies suggest that these transcription factors act in a cascade aiding in the development of adipose cells.
Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation and display different functions in gene regulation.
From a neurological standpoint, C/EBPs have been implicated in the mediation of nerve growth factor, altering synaptic plasticity, and mediation of inflammatory response in Alzheimer's disease patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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