Thermo Fisher Scientific ATM Monoclonal Antibody (2C10)

Applications

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MTLHEPANSS ASQSTDLCDF SGDLDPAPNP PHFPSHVVKA TFAYISNCHK TKLKSILEIL SKSPDSYQKI LLAICEQAAE TNNVYKKHRI LKIYHLFVSL LLKDIKSGLG GAWAFVLRDV IYTLIHYINQ RKLTIFSQ

Target Information

Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family.
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and an increased risk of lymphoid cancer.

The ATM gene encodes a protein in the phosphoinositide 3-kinase (PI3K) superfamily. ATM phosphorylates proteins instead of lipids and has many downstream targets that act as cell-cycle regulators, including P53, Mdm2, BRCA1, and SMC1.

ATM is responsible for repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens. The C-terminal region of ATM shows extensive homology to catalytic domains of PI3 kinases. Studies indicate that ATM becomes autophosphorylated and upregulated upon ionizing radiation exposure.

AT cells are hypersensitive to ionizing radiation, show impaired inhibition of DNA synthesis, and display delays in p53 induction. DNA damage activates ATM kinase, triggering a cascade of kinase reactions regulating cell cycle, apoptosis, and DNA damage repair.

ATM has also been linked to apoptosis along with Nbs1 and Chk2 in the E2F1 pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.