Thermo Fisher Scientific ATOH1 Monoclonal Antibody (3B12)
ATOH1 단백질을 인식하는 Mouse Monoclonal Antibody (Clone 3B12). Western blot, ICC/IF, ELISA에 사용 가능. 인간 반응성, 액상 형태, PBS 버퍼에 보존제 없음. 연구용으로만 사용.
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- H00000474-M06
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Thermo Fisher Scientific ATOH1 Monoclonal Antibody (3B12)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B12 |
| Immunogen | ATOH1 (NP_005163.1, 266–354 a.a.) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
PTPPGSCRTR FSAPASAGGY SVQLDALHFS TFEDSALTAM MAQKNLSPSL PGSILQPVQE ENSKTSPRSH RSDGEFSPHS HYSDSDEAS
Target Information
The Drosophila atonal gene produces a protein with basic helix-loop-helix (bHLH) domains that plays an essential role in the development of the Drosophila nervous system.
Mammalian atonal homolog 1 (MATH-1) is a helix-loop-helix (HLH) transcription factor structurally homologous to the product of the Drosophila proneural gene atonal. MATH-1 (also known as Atoh1, Ath1, or HATH-1) is a 351 amino acid protein with an atonal-related basic HLH domain.
In mice, expression of MATH-1 begins by embryonic day 9.5, initially localizing to the cranial ganglions and dorsal part of the central nervous system. Expression becomes restricted to the external granular layer of the cerebellum by day 18 and is undetectable in the adult nervous system.
It is suggested that MATH-1 may play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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