Thermo Fisher Scientific ATOH1 Monoclonal Antibody (3B12)

Thermo Fisher Scientific ATOH1 Monoclonal Antibody (3B12)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
PTPPGSCRTR FSAPASAGGY SVQLDALHFS TFEDSALTAM MAQKNLSPSL PGSILQPVQE ENSKTSPRSH RSDGEFSPHS HYSDSDEAS

Target Information

The Drosophila atonal gene produces a protein with basic helix-loop-helix (bHLH) domains that plays an essential role in the development of the Drosophila nervous system.
Mammalian atonal homolog 1 (MATH-1) is a helix-loop-helix (HLH) transcription factor structurally homologous to the product of the Drosophila proneural gene atonal. MATH-1 (also known as Atoh1, Ath1, or HATH-1) is a 351 amino acid protein with an atonal-related basic HLH domain.

In mice, expression of MATH-1 begins by embryonic day 9.5, initially localizing to the cranial ganglions and dorsal part of the central nervous system. Expression becomes restricted to the external granular layer of the cerebellum by day 18 and is undetectable in the adult nervous system.
It is suggested that MATH-1 may play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.