Thermo Fisher Scientific STAT5A Monoclonal Antibody (PCRP-STAT5A-1A9)

Applications

Product Specifications

Product Specific Information

This antibody is predicted to work with Mouse and Rat.

Target Information

STAT5 alpha is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases and then form homo- or heterodimers that translocate to the cell nucleus, acting as transcription activators. STAT5 alpha mediates responses to ligands such as IL2, IL3, IL7, GM-CSF, erythropoietin, thrombopoietin, and various growth hormones. Its activation in myeloma and lymphoma associated with TEL/JAK2 fusion is independent of cell stimulus and essential for tumorigenesis. The mouse counterpart induces BCL2L1/BCL-X(L) expression, suggesting an anti-apoptotic role. STAT5 alpha and STAT5 beta share 96% sequence similarity and are co-expressed in most tissues, though their mRNA levels differ in muscle and mammary tissue. STAT5 alpha is critical in reproduction, lactation, immune function, and somatic growth.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.