Thermo Fisher Scientific STAT5B Monoclonal Antibody (STAT5B, 2611)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Peptide Array (Array)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature (RT).
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at RT for 20 min.

Target Information

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases, then form homo- or heterodimers that translocate to the nucleus to act as transcription activators.
STAT5B mediates signal transduction triggered by ligands such as IL2, IL4, CSF1, and growth hormones. It is involved in processes including TCR signaling, apoptosis, mammary gland development, and sexual dimorphism of liver gene expression.
STAT5B has been found fused to the RARA gene in a subset of acute promyelocytic leukemias (APLL), and dysregulation of its signaling may contribute to disease pathogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.