Thermo Fisher Scientific STAT5A Monoclonal Antibody (PCRP-STAT5A-1A9)
STAT5A 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단클론 항체입니다. 인간 시료에 반응하며 ICC/IF, Flow Cytometry, Peptide Array에 적합합니다. 단백질 A/G로 정제된 액상 형태로, 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL | - |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells | - |
| Peptide Array (Array) | Assay-dependent | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PCRP-STAT5A-1A9 |
| Immunogen | Protein domain of STAT5A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
This antibody is predicted to work with Mouse and Rat samples.
Target Information
STAT5 alpha is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases and then form homo- or heterodimers that translocate to the nucleus to act as transcription activators. STAT5 alpha is activated by multiple ligands such as IL2, IL3, IL7, GM-CSF, erythropoietin, thrombopoietin, and various growth hormones.
Activation of STAT5 alpha in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and essential for tumorigenesis. The mouse counterpart induces expression of BCL2L1/BCL-X(L), suggesting an antiapoptotic function. STAT5 alpha and STAT5 beta share 96% sequence similarity and are co-expressed in most tissues, with differential mRNA accumulation in muscle and mammary tissue. STAT5 alpha is critically involved in reproduction, lactation, immune function, and somatic growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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