Thermo Fisher Scientific STAT5B Monoclonal Antibody (STAT5B, 2611)
STAT5B 단백질을 인식하는 마우스 단클론 항체로, 인간 시료에 반응합니다. IHC(P) 및 Peptide Array에 사용 가능하며, 단백질 A/G로 정제된 액상 항체입니다. PBS 완충액에 0.05% BSA와 sodium azide가 포함되어 있으며 4°C 보관합니다.
- 카탈로그번호
- 6777-MSM1-P1
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific STAT5B Monoclonal Antibody (STAT5B, 2611)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | STAT5B, 2611 |
| Immunogen | Recombinant full-length human STAT5B protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- For formalin-fixed tissues: Heat tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, then cool at room temperature for 20 minutes before staining.
Target Information
The STAT5B protein is a member of the STAT family of transcription factors. Upon stimulation by cytokines and growth factors, STAT proteins are phosphorylated by receptor-associated kinases, form homo- or heterodimers, and translocate to the nucleus to function as transcription activators.
STAT5B mediates signaling triggered by ligands such as IL2, IL4, CSF1, and various growth hormones. It participates in biological processes including TCR signaling, apoptosis, mammary gland development, and liver gene expression regulation.
In some cases of acute promyelocytic leukemia (APLL), STAT5B has been found to fuse with the retinoic acid receptor-alpha (RARA) gene. Dysregulation of STAT5B-mediated pathways may contribute to APLL pathogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.