Thermo Fisher Scientific RLTPR Monoclonal Antibody (EM-53), PE
RLTPR/CARMIL2 단백질을 인식하는 EM-53 클론의 단클론 항체로, PE 형광 표지된 제품입니다. Flow Cytometry에 적합하며 Mouse 및 Human 시료에 반응합니다. 액상 형태로 제공되며 4°C 암소 보관이 필요합니다.
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Applications
- Flow Cytometry (Flow): Tested Dilution 1–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | EM-53 |
| Immunogen | Murine Rltpr (amino acids 1147–1397) |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745590 |
Additional Formats
Product Specific Information
This antibody recognizes RLTPR / CARMIL2, an intracellular protein playing a role in actin filament elongation.
Target Information
RLTPR/CARMIL2 (RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing; capping protein regulator and myosin 1 linker 2), also known as LRRC16C, is a cytosolic protein that binds CAPZA2 (capping protein muscle actin Z-line alpha 2) and modulates actin filament elongation.
It is essential for lamellipodial protrusion, cell translocation, and T cell costimulation via CD28, independent of actin-uncapping function.
Deficiency of functional RLTPR/CARMIL2 leads to combined immunodeficiency and impaired Th1/Th17 differentiation.
Expression also occurs in human and murine B cells, though not involved in BCR-mediated signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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