Thermo Fisher Scientific RLTPR Monoclonal Antibody (EM-53)
RLTPR/CARMIL2 단백질을 인식하는 mouse monoclonal antibody (clone EM-53). Western blot과 Flow cytometry에 사용 가능. Protein A 정제, 1 mg/mL 농도의 액상 형태. PBS buffer에 15 mM sodium azide 포함, 4°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Flow Cytometry (Flow) | 1–4 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | EM-53 |
| Immunogen | Murine Rltpr (Antigen range: 1–1296, UniProt ID: Q3V3V9-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745591 |
Additional Formats
Product Specific Information
This antibody recognizes RLTPR / CARMIL2, an intracellular protein that plays a role in actin filament elongation.
Target Information
RLTPR/CARMIL2 (RGD motif, leucine-rich repeats, tropomodulin domain, and proline-rich containing; capping protein regulator and myosin 1 linker 2), also known as LRRC16C, is a cytosolic protein that binds CAPZA2 (capping protein muscle actin Z-line alpha 2) with high affinity and decreases its affinity for actin barbed ends.
RLTPR/CARMIL2 increases actin filament elongation rate in the presence of CAPZA2 but does not nucleate filaments. Its interaction with CAPZA2 is essential for lamellipodial protrusion and cell translocation.
It is crucial for T cell costimulation via CD28, independent of its actin-uncapping function. Lack of functional RLTPR/CARMIL2 impairs Th1 and Th17 differentiation in human and murine CD4+ T cells, leading to combined immunodeficiency.
Expression is also detected in human and murine B cells, though it is not involved in BCR-mediated signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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