Thermo Fisher Scientific Phospho-LKB1 (Ser428) Polyclonal Antibody
Phospho-LKB1 (Ser428) 폴리클로날 항체로 인간, 마우스, 영장류 반응성. Western blot, IHC, ICC/IF에 사용 가능. 인산화된 Ser428 위치의 LKB1 단백질만 검출. 세포 내 신호전달 및 암 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human STK11 (Accession Q15831), corresponding to amino acid residues around phosphorylated Ser428 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816477 |
Product Specific Information
This antibody detects endogenous levels of LKB1 only when phosphorylated at Serine 428.
Target Information
LKB1 (also known as STK11 - Serine/threonine-protein kinase STK11) is a tumor suppressor belonging to the serine/threonine kinase family.
It physically associates with p53 and regulates specific p53-dependent apoptosis pathways.
LKB1 is localized in both the cytoplasm and nucleus and translocates to mitochondria during apoptosis.
It functions as a master upstream protein kinase regulating AMPK-related kinases as well as AMPK.
Mutations in the LKB1 gene are associated with Peutz-Jeghers syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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