Thermo Fisher Scientific Phospho-SMAD1 (Ser465) Polyclonal Antibody
SMAD1 단백질의 Ser465 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. 인체, 생쥐, 랫드 반응성. 고순도 정제 및 안정적 PBS/glycerol 저장 포맷.
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Thermo Fisher Scientific Phospho-SMAD1 (Ser465) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SMAD1 (Accession Q15797), corresponding to amino acid residues around phosphorylated Ser465 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816475 |
Product Specific Information
This antibody detects endogenous levels of Smad1 only when phosphorylated at Serine 465.
Target Information
SMAD1 belongs to the SMAD family, which includes proteins homologous to the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators mediating multiple signaling pathways.
SMAD1 mediates bone morphogenetic protein (BMP) signals that regulate cell growth, apoptosis, morphogenesis, development, and immune responses. Upon BMP ligand binding, SMAD1 is phosphorylated and activated by BMP receptor kinases, forming a complex with SMAD4 for transcriptional regulation.
SMAD1 is a target for SMURF1 and SMURF2 E3 ubiquitin ligases and undergoes ubiquitination and proteasomal degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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