Thermo Fisher Scientific SRPK2 Polyclonal Antibody
SRPK2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, IP 등 다양한 응용에 적합합니다. 4°C에서 보관하며, 액상 형태로 제공됩니다. HBV 감염 및 세포 내 인산화 연구에 유용한 연구용 항체입니다.
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 425 and 475 of Human SFRS protein kinase 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
SRPK2, along with SRPK1, is likely the cellular protein kinase mediating HBV core protein phosphorylation during viral infection, representing an important host cell target for therapeutic intervention in HBV infection.
It promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression through phosphorylation of SRSF2, leading to suppression of p53/TP53 phosphorylation and relieving its repressive effect on cyclin-D1 expression.
SRPK2 phosphorylates ACIN1, redistributing it from nuclear speckles to the nucleoplasm, resulting in up-regulation of cyclin A1 but not cyclin A2. It plays an essential role in spliceosomal B complex formation via phosphorylation of DDX23/PRP28 and negatively regulates HBV replication by reducing pregenomic RNA packaging efficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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