Thermo Fisher Scientific SRPK2 Polyclonal Antibody
SRPK2 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody로, WB, IHC, IP 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 인간 시료에 반응합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 425 and 475 of Human SFRS protein kinase 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
SRPK2, along with SRPK1, is a cellular protein kinase mediating HBV core protein phosphorylation during viral infection. It is an important host cell target for therapeutic intervention in HBV infection.
Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression through phosphorylation of SRSF2, leading to suppression of p53/TP53 phosphorylation.
Phosphorylates ACIN1 and redistributes it from nuclear speckles to nucleoplasm, resulting in cyclin A1 up-regulation.
Plays an essential role in spliceosomal B complex formation via phosphorylation of DDX23/PRP28.
Negatively regulates HBV replication by reducing packaging efficiency of pregenomic RNA (pgRNA) without affecting viral core particle formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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