Thermo Fisher Scientific Phospho-Dynamin 1 (Ser778) Polyclonal Antibody
Phospho-Dynamin 1 (Ser778) 폴리클로날 항체로, 인산화된 Dynamin 1의 Ser778 위치를 특이적으로 검출. Western blot에 적합하며, 인간·생쥐·흰쥐 시료 반응. 고순도 정제, PBS/glycerol 저장, 연구용 전용.
- 카탈로그번호
- PA599143
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 1:500–1:2,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DNM1 (Accession Q05193), corresponding to amino acid residues around phosphorylated Ser778 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818076 |
Product Specific Information
Antibody detects endogenous levels of DYN1 only when phosphorylated at Serine 778.
Target Information
Dynamin is a GTPase required for endocytosis of clathrin-coated vesicles from the membrane. Its role was first identified in Drosophila melanogaster through the temperature-sensitive shibire mutation.
Mammals have three closely related isoforms:
- Dynamin 1: Expressed exclusively in neurons
- Dynamin 2: Ubiquitously expressed
- Dynamin 3: Expressed primarily in testes
Each isoform has several splice variants, suggesting distinct intracellular targets or vesicle budding functions.
Common structural domains include:
- N-terminal GTPase domain
- Central pleckstrin homology domain
- Proline-rich C-terminal region with Src homology 3 (SH3) domains
These SH3 domains mediate interactions with clathrin-coated pits and proteins such as AP2 adaptor complex and amphiphysin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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