Thermo Fisher Scientific PGP9.5 Polyclonal Antibody
PGP9.5 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC 등 다양한 응용에 적합. 인간, 마우스, 랫트 등 반응성. 신경세포 마커로 신경퇴행성 질환 연구에 활용 가능. 4°C 단기, -20°C 장기 보관 권장.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 | - |
| Immunocytochemistry (ICC/IF) | 1:250 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Pig, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues A(176)SSEDTLLKDAAKVCR(191) of human PGP9.5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_560759 |
Product Specific Information
- Recommended positive controls: Human brain lysate
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PGP9.5 (Protein gene product 9.5, also known as UCH-L1 or PARK5) is a neuron-specific protein, structurally and immunologically distinct from neuron-specific enolase. It has a molecular weight of 27 kDa and belongs to the ubiquitin carboxyl-terminal hydrolase family (peptidase family C12). PGP9.5 exhibits ubiquitin hydrolase and ligase activities, hydrolyzing small C-terminal adducts of ubiquitin to generate monomers.
It is expressed in neurons and nerve fibers throughout the central and peripheral nervous systems, as well as in neuroendocrine cells, renal tubules, spermatogonia, Leydig cells, ova, and corpus luteum cells. Overexpression is associated with non-small cell lung cancer, while decreased expression relates to Huntington and Alzheimer diseases. PGP9.5 serves as a valuable neuronal marker and is used in studies of neurodegenerative disorders such as Parkinson disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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