Thermo Fisher Scientific ACVR2A Polyclonal Antibody
Goat에서 유래한 ACVR2A 폴리클로날 항체로, Western blot, IHC, ELISA에 적합. Activin A receptor kinase 검출 및 신호전달 연구용. 비결합형 액상 형태로 4°C 또는 -20°C 보관 권장.
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 15 µg/mL |
| ELISA | 0.5–1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment of human Activin Receptor Type IIA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2222297 |
Product Specific Information
- Recommended positive controls: muscle fibroblasts
- Neutralization: when used at 1–3 µg/mL, the antibody blocks 50% of the binding of 30 ng/mL recombinant human activin A to immobilized recombinant human activin receptor IIA/Fc chimera (100 µL of a 0.5 µg/mL solution coating each well) in a functional ELISA assay.
Target Information
Activin A receptor kinase (ACVR2A) is a type II receptor in the TGF-beta family of receptor serine/threonine kinases.
ACVR2A is involved in activin and myostatin signaling pathways.
Aliases: ACVR2, ACTRII.
These receptors are transmembrane proteins composed of:
- Ligand-binding extracellular domain with cysteine-rich region
- Transmembrane domain
- Cytoplasmic domain with serine/threonine kinase specificity
Type I receptors are essential for signaling, while type II receptors bind ligands and enable type I receptor expression.
Upon ligand binding, type I and II receptors form a stable complex, leading to phosphorylation of type I receptors by type II receptors.
Type II receptors are constitutively active kinases.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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